Patient and public engagement in clinical trials

Clinician engagement is critical to public engagement with clinical trials.

Five years on from Godlee and Chalmers’ advocacy of greater patient information to improve access to clinical trials,we have conducted research showing that engaging clinicians with local research and trial information is as critical to enabling participation as are public engagement and information provision. Our study explored the perceptions, motivations, and barriers to trial participation ...

When participants get involved: reconsidering patient and public involvement in clinical trials at the MRC Clinical Trials Unit at UCL

BACKGROUND Patient and public involvement (PPI) in clinical trials aims to ensure that research is carried out collaboratively with patients and/or members of the public. However, current guidance on involving clinical trial participants in PPI activities is not consistent. METHODS We reviewed the concept of participant involvement, based on our experience. Two workshops were held at the MRCC...

Patient confidence in clinical trials.

Patient-centered clinical trials.

We apply Bayesian decision analysis (BDA) to incorporate patient preferences in the regulatory approval process for new therapies. By assigning weights to type I and type II errors based on patient preferences, the significance level (α) and power (1-β) of a randomized clinical trial (RCT) for a new therapy can be optimized to maximize the value to current and future patients and, consequently,...

A mapping and gapping analysis of patient and public involvement in a clinical trials unit

Patient and public involvement (PPI) in research involves the active contribution of members of the public in research studies and within research organisations. PPI is important in ensuring the relevance and quality of general health care research. Funders often now request evidence of prior and future planned PPI in health research. The University of Liverpool Clinical Trials Research Centre ...